PESQUISA VETERINÁRIA BRASILEIRA

Abstract in English:

ABSTRACT.- Furlan F.H., Lucioli J., Borelli V., Fonteque J.H., Stolf L., Traverso S.D. & Gava A. 2009. [Poisoning by closantel in sheep and goats in the State of Santa Catarina, Brazil.] Intoxicação por closantel em ovinos e caprinos no Estado de Santa Catarina. Pesquisa Veterinária Brasileira 29(1):89-93. Departamento de Medicina Veterinária, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Lages, SC 88520-000, Brazil. E-mail: a2ag@cav.udesc.br Two outbreaks of closantel overdosage in sheep and goat flocks are described. In the first outbreak 12 sheep were affected, 5 of them showed blindness, three sheep died (Sheep 1-3) and two were euthanized 6 months after the onset of clinical manifestation (Sheep 4 and 5). In the second outbreak 26 goats were affected, from which six survived despite blindness and one was euthanized. Clinically the animals showed depression, ataxia, motor incoordination, decreased or absent pupil reflexes. In some animals this clinical picture developed to bilateral blindness, with no reaction to threat and bilateral irresponsive midriasis. In the ophthalmic examination retinal vessel atrophy and hyperreflexia were observed. The histological examination showed myelin edema leading to status spongiosus in the central nervous system and compressive neuropathy of the optic nerve, associated with retinal degeneration and/or atrophy. This report aims to describe the epidemiologic, clinic and pathologic aspects of closantel overdosage in sheep and goats.

• Closantel sheep goats status spongiosus retinal degeneration

Abstract in Portuguese:

ABSTRACT.- Furlan F.H., Lucioli J., Borelli V., Fonteque J.H., Stolf L., Traverso S.D. & Gava A. 2009. [Poisoning by closantel in sheep and goats in the State of Santa Catarina, Brazil.] Intoxicação por closantel em ovinos e caprinos no Estado de Santa Catarina. Pesquisa Veterinária Brasileira 29(1):89-93. Departamento de Medicina Veterinária, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Lages, SC 88520-000, Brazil. E-mail: a2ag@cav.udesc.br Two outbreaks of closantel overdosage in sheep and goat flocks are described. In the first outbreak 12 sheep were affected, 5 of them showed blindness, three sheep died (Sheep 1-3) and two were euthanized 6 months after the onset of clinical manifestation (Sheep 4 and 5). In the second outbreak 26 goats were affected, from which six survived despite blindness and one was euthanized. Clinically the animals showed depression, ataxia, motor incoordination, decreased or absent pupil reflexes. In some animals this clinical picture developed to bilateral blindness, with no reaction to threat and bilateral irresponsive midriasis. In the ophthalmic examination retinal vessel atrophy and hyperreflexia were observed. The histological examination showed myelin edema leading to status spongiosus in the central nervous system and compressive neuropathy of the optic nerve, associated with retinal degeneration and/or atrophy. This report aims to describe the epidemiologic, clinic and pathologic aspects of closantel overdosage in sheep and goats.